Weight loss drugs, known as GLP-1 receptor agonists or semaglutides are becoming popular. These drugs are likely better than being overweight, though I prefer addressing obesity through diet, exercise, and lifestyle changes. If someone chooses to use these medications long-term, research shows they can improve health.
The main concern with GLP-1 drugs for weight loss is that they don't require lifestyle changes. Traditional weight loss methods involve strength training, walking, eating more protein, and cutting out processed foods. These habits build muscle, reduce body fat, and improve body composition. GLP drugs don't require these changes; they handle weight loss for you.
If you decide to use weight loss drugs, consider these suggestions:
Focus on protein intake. Your appetite will decrease significantly, but aim for at least 100-120 grams of quality protein daily.
Muscle loss is a common side effect of GLP-1 drugs. Human studies show more muscle loss compared to low-carb, high-protein diets.
Use whey protein isolate. Adding 20-40 grams to drinks can help prevent muscle loss when eating solid food is difficult.
Do strength training. Use heavier weights with fewer repetitions to preserve muscle mass without overexerting yourself.
Stay active. Research suggests that people who exercise while taking GLP-1 drugs have better outcomes if they stop using the medication.
Be aware of potential side effects:
- Gastroparesis: Slow digestion causing nausea, vomiting, and constipation.
- Increased resting heart rate: Some patients experience this effect.
- Anhedonia: Reduced dopamine levels may lead to a lack of pleasure in daily life.
While these weight loss drugs can be helpful, understand that their fat-loss mechanism may have other unintended effects.
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Here's some more information from the Mayo Clinic.
Prescription weight loss drugs: Can they help you?